Study	Cohort (N)	M:F	Age (Mean)	Cohort of Interest	Nerve Target	Treatment Parameters	Cryoneurolysis Method
[c@383720]	100	30:70	66.4 (9.4)	TKA	AFCN, IPBSN	Cryoneurolysis plus multimodal pain management was performed 5 days before surgery	Iovera
[c@383718]	114	57:57	68.5 (8.2)	Patients ages 22-79 who underwent primary unilateral TKA due to osteoarthritis and had an anticipated discharge to home following the procedure	AFCN, IPBSN	Cryoneurolysis 3-7 days before TKA	Iovera
[c@383713]	96	45:51	66.1 (7.7)	Patients ages 22-79 who were scheduled to undergo primary unilateral TKA as a result of osteoarthritis with anticipated discharge to home	AFCN, IPBSN	Cryoneurolysis 3-7 days before TKA	Iovera
[c@383716]	57	20:37	68 ± 7	Patients who underwent TKA by a fellowship-trained orthopaedic surgeon	AFCN, IPBSN	Cryoneurolysis 1 week before TKA	Iovera
[c@383724]	16	6:10	68 (64–72)	Patients ages 18 years or older presenting for unilateral primary total knee arthroplasty with a planned single-injection or continuous adductor canal block	IPBSN	Single-injection adductor canal nerve block was performed before randomization to the cryoneurolysis group. The patient then immediately underwent TKA following cryoneurolysis	A 14-gauge cryoneurolysis probe connected to a console-based cryoneurolysis machine (PainBlocker, Epimed International, Farmers Branch, TX)
[c@383714]	267	102:165	66 (9)	Optimized preoperative cryoneurolysis to all patients undergoing TKA as part of its standard multimodal perioperative pain protocol	AFCN, IPBSN	Administered to conscious patients after local anesthesia 8-11 days before TKA	Iovera
Deventer et al. (2023)	144	44:100		Consecutive patients who underwent primary unilateral TKA by a single fellowship-trained orthopedic surgeon between January 2019 and August 2021 using an enhanced recovery TKA protocol. All patients underwent cryoneurolysis	AFCN, IPBSN	Cryoneurolysis 5 days before TKA	Iovera